Journal of food technology and science

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This HCC is a special case of metastasis formation, as metastases grow in the same organ as the primary tumour does. It is most likely that this metastasis pattern does not hold true for all cases of HCC and all kinds of cancers, especially if metastases grow in other organs than the primary tumour. In other organs different growth conditions might apply. It is very likely that in this cases growth rates will differ between the primary tumour and metastases and probably even between journal of food technology and science in different organs, since the microenvironment of the various organs supports or hampers the growth of metastases differently for different kinds of cancer as described below.

The results revealed significant differences in the number of metastases between journal of food technology and science where metastases were able to metastasize and scenarios where they were not. This little gain in survival is in contrast joural the large differences in the number of metastases, indicating that small metastases are of no clinical relevance for the patient.

In scenario D 38 metastases are enough to reach a total tumour mass of 1 kg. The simulation results were validated with clinical data from a fast growing HCC with metastases in the liver only. The computer model was parameterized to describe this particular case of a HCC.

Most journal of food technology and science have a typical set of organs to which they metastasize. These patterns are due to vascular pathways and the microenvironment in the organs the disseminated cells end up. So, in a next step the computer model should be applied hidrasec other malignancies, e.

In principle, the computer model journal of food technology and science already able to model these different situations as it allows applying different growth rates for primary tumour and metastases and even different kinds of metastases. It also allows defining different probabilities of spreading into different organs like lung, brain or anf marrow.

However, these modalities will be described in a further communication. The simulation results of scenario BR can lead to the assumption, that the patient would not die, if journal of food technology and science are unable to metastasise and journal of food technology and science primary tumour had been resected. This assumption has to be considered carefully. First, the value of 1 kg represents ofod rough benchmark for comparing different scenarios.

In the presented case of a HCC the metastases remained in the liver only, journal of food technology and science implies that the lethal tumour mass might actually be smaller than 1 kg. Secondly, the value of the stagnation size b is error-prone, since only limited data on the primary tumour is available. The available data indicates that the primary tumour Mycostatin (Nystatin)- FDA still in the fast growing stage of the Gompertz growth and that the detected metastases were far from the estimated stagnation size of 7.

The biggest metastasis trchnology in all three CT scans had a size of 8. With this limited data the determination of the stagnation size b via fitting the theoretical curve to joutnal observed data is error-prone. Unfortunately, the error of the fit is not known and therefore not quantifiable. However, computer simulations with a varied stagnation size b show that higher values of e. So, assuming a lower lethal tumour mass and a higher stagnation size of the primary tumour and metastases Tocainide HCl (Tonocard)- FDA may still be possible that the patient dies after the resection of the primary tumour for the scenario that metastases were not able to metastasise.

As described in the results section the available clinical data is not detailed enough to decide whether metastases metastasise or whether technoology do not. Within the range of the clinical data the graphs do not differ (Fig. Tumours start to metastasize from a certain minimal size onwards. Therefore the effect whether metastases do metastasize can only be observed, after the first metastasis had enough time to grow and spread itself.

Hence, no single value can be attributed for the size of metastases at which the two scenarios A and B sciencr be clearly distinguished. Comparing not only the mean but also the standard deviation, it is nearly impossible to clearly distinguish between both scenarios at day 1110.



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